AMD EPYC 7451 's Advantages
Released 9 years and 10 months late
Higher specification of memory (DDR4-2666 vs DDR2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)
Opteron 2222 's Advantages
Higher base frequency (3GHz vs 2.3GHz)
Lower TDP (95W vs 180W)