Intel Xeon E5 2643 's Advantages
Higher base frequency (3.3GHz vs 2GHz)
Lower TDP (130W vs 300W)
Intel Xeon Platinum 8452Y 's Advantages
Released 10 years and 10 months late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (67.5MB vs 10MB)
More modern manufacturing process (10nm vs 32nm)