Opteron 2216 HE (F2) 's Advantages
Higher base frequency (2.4GHz vs 2GHz)
Lower TDP (68W vs 170W)
AMD EPYC 7401 's Advantages
Released 10 years and 10 months late
Higher specification of memory (2666 vs 2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)