Opteron 4340 's Advantages
Higher base frequency (3.5GHz vs 2.7GHz)
Lower TDP (95W vs 205W)
Xeon Platinum 8280 's Advantages
Released 6 years late
Higher specification of memory (4 vs 3)
Larger L3 cache size (38.5MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)