Opteron 6180 SE 's Advantages
Released 4 years and 6 months late
Higher specification of memory (1333 vs 2)
Newer PCIe version (2 vs 1)
More modern manufacturing process (45nm vs 90nm)
Opteron 2220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.5GHz)
Lower TDP (119W vs 140W)