Opteron 6378 's Advantages
Lower TDP (115W vs 320W)
AMD EPYC 9384X 's Advantages
Released 10 years and 7 months late
Higher specification of memory (4800 vs 1866)
Newer PCIe version (5 vs 2)
Higher base frequency (3.1GHz vs 2.4GHz)
Larger L3 cache size (768MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)