Opteron 6378 's Advantages
Released 5 years and 3 months late
Higher specification of memory (1866 vs 667)
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)
Opteron 8222 's Advantages
Higher base frequency (3GHz vs 2.4GHz)
Lower TDP (95W vs 115W)