Opteron 6378 's Advantages
Higher specification of memory (1866 vs 4)
Lower TDP (115W vs 205W)
Xeon Platinum 8280 's Advantages
Released 6 years and 1 months late
Higher base frequency (2.7GHz vs 2.4GHz)
Larger L3 cache size (38.5MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)