Opteron 6386 SE 's Advantages
Lower TDP (140W vs 280W)
AMD EPYC 9354 's Advantages
Released 10 years late
Higher specification of memory (4800 vs 1600)
Newer PCIe version (5 vs 2)
Higher base frequency (3.25GHz vs 2.8GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)