Opteron 8220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.5GHz)
Opteron 6380 's Advantages
Released 6 years and 3 months late
Higher specification of memory (1866 vs 667)
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)
Lower TDP (115W vs 120W)