AMD Radeon Pro WX 9100 's Advantages
More VRAM (16GB vs 4GB)
Larger VRAM bandwidth (483.8GB/s vs 128.0GB/s)
3328 additional rendering cores
AMD Radeon RX 6400 's Advantages
Released 4 years and 6 months late
Boost Clock has increased by 55% (2321MHz vs 1500MHz)
Lower TDP (53W vs 230W)