AMD EPYC 7281 's Advantages
Higher base frequency (2.1GHz vs 1.9GHz)
Lower TDP (170W vs 250W)
Xeon 6766E 's Advantages
Released 7 years late
Higher specification of memory (6400 vs 2666)
Newer PCIe version (5 vs 3)
Larger L3 cache size (108MB vs 32MB)
More modern manufacturing process (5nm vs 14nm)