AMD EPYC 7451 's Advantages
Lower TDP (180W vs 290W)
AMD EPYC 9454 's Advantages
Released 5 years and 5 months late
Higher specification of memory (DDR5-4800 vs DDR4-2666)
Newer PCIe version (5 vs 3)
Higher base frequency (2.75GHz vs 2.3GHz)
Larger L3 cache size (256MB vs 64MB)
More modern manufacturing process (5nm vs 14nm)