Opteron 3380 's Advantages
Lower TDP (65W vs 290W)
AMD EPYC 9454 's Advantages
Released 9 years and 11 months late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 2)
Higher base frequency (2.75GHz vs 2.6GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)