Opteron 6376 's Advantages
Lower TDP (115W vs 200W)
AMD EPYC 9255 's Advantages
Released 11 years and 11 months late
Higher specification of memory (6000 vs 1866)
Newer PCIe version (5 vs 2)
Higher base frequency (3.25GHz vs 2.3GHz)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (4nm vs 32nm)