Opteron 6378 's Advantages
Higher base frequency (2.4GHz vs 2.1GHz)
Lower TDP (115W vs 120W)
AMD EPYC 7251 's Advantages
Released 4 years and 7 months late
Higher specification of memory (2400 vs 1866)
Newer PCIe version (3 vs 2)
Larger L3 cache size (32MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)