Opteron 6378 's Advantages
Higher base frequency (2.4GHz vs 2GHz)
Lower TDP (115W vs 500W)
Xeon 6980P 's Advantages
Released 11 years and 10 months late
Higher specification of memory (8800 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (504MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)