Opteron 8216 (F2) 's Advantages
Higher base frequency (2.4GHz vs 2.1GHz)
Lower TDP (95W vs 250W)
Intel Xeon Platinum 9221 's Advantages
Released 12 years and 8 months late
Higher specification of memory (2933 vs 667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)